Senior Scientist – Formulation Science
Senior Scientist – Formulation Science
Location: Macclesfield, UK
Salary Competitive and flexible benefits package
Introduction to role
Join AstraZeneca, a global, science-driven biopharmaceutical company dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions. We are looking for an enthusiastic and highly capable Senior Scientist - Formulation to join our Early Product Development and Manufacturing (EPDM) team. In this role, you will collaborate closely with analytical, solid-state, and biopharmaceutics scientists within EPDM, as well as with colleagues from other functions, to drive scientific innovation within drug projects. Be part of a team where you are empowered to follow the science! Be part of the team where you are empowered to follow the science!
Accountabilities
As a Senior Scientist you will:
Plan/Perform pre-formulation studies of APIs based on the available preclinical data to develop a strategy for clinical dosage forms.
Designing robust oral formulations for early clinical studies that meets patient needs target product profile.
Driving scientific product design, process, and product performance understanding to influence strategies in early product development, with a line of sight to late-stage development.
Planning and conducting lab-based experimental work to achieve optimal products ready for scale-up to clinical plans in accordance with project timelines.
A strong presence in the laboratory, acting as a role model for less experienced colleagues
Keeping abreast of scientific literature and proactively applying existing and novel approaches to projects.
Representing the formulation skill area in projects to drive science and innovation.
Collaborating closely with analytical, manufacturing, biopharmaceutics, and solid-state scientists within EPDM, as well as external collaborators, to ensure all goals are met.
Essential Skills/Experience:
• Degree (preferably Masters or PhD or equivalent experience) in Pharmaceutical Sciences or a related subject.
• Excellent track record of formulating and characterising a variety of dosage forms.
• Experience in formulation and process development of poorly soluble molecules.
• Experience in managing outsourced activities at Contract Manufacturing Organizations (CMOs).
• Track record as a scientific leader, providing scientific challenge and direction to colleagues.
Desirable Skills/Experience
• Proven leadership in the scientific subject area of formulation.
• In-depth understanding of how the physicochemical and solid-state properties of the drug affect absorption.
• Track record of authoring high-quality regulatory submissions for IND/IMPD.
• Ability to challenge the status quo and implement a culture of continuous improvement.
• Global mentality and ability to work across multiple geographical locations.
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. This is a lab based role so will be lab based five days per week, but that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
At AstraZeneca, we are driven by our desire to understand and reveal new insights. We are free from fear of failure, free to ask the right questions, make bold decisions, and dig deep into the biology of complex diseases. We take inspiration from within our BioPharmaceutical heritage, as well as beyond, exploring what we can take and apply. We are always listening and learning from people who live with the diseases our medicines treat. It enables us to better understand their needs and, ultimately, diagnose and design the right treatments to impact patients' lives.
Are you ready to join a team that follows the science unlike anywhere else? This is the place for curious minds. Dig deep into the biology of complex disease and uncover breakthroughs. Our belief powers us to push the boundaries. As we improve success rates, we keep moving forward. Celebrating both successes and failures along the way.
Ready to make an impact? Apply now!
We welcome your application before the 23rd September.
Please note that we may reach out before the closing date
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
