Senior Scientist, Early Bioprocess Research
Join us at AstraZeneca where you'll have the opportunity to make a difference in people's lives every day. As a Senior Scientist in the Early Bioprocess Research team within Early Vaccines & Immune Therapies R&D (Early V&I) in Seattle, WA, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on patients’ lives. We are consistently pushing the boundaries of science to deliver life-changing medicines to patients.
SUMMARY:
Currently, we are seeking a Senior Scientist in our Seattle, WA location with a strong protein biochemistry background to lead early bioprocess activities for preclinical vaccine pipeline programs. This will be a key member of the team developing next-generation vaccines. The position requires both the ability to lead collaborative team activities and a strong curiosity about laboratory bench work for driving projects forward.
Position is located in Seattle, WA
RESPONSIBILITIES:
Independently crafts and drives studies for screening and optimization of preclinical vaccine candidates including expression, purification, characterization, formulation, and stability testing of recombinant proteins.
Identifies and troubleshoots issues with processes, methods and/or results.
Designs, develops and implements analytical assays (BLI, SEC-MALS, DLS, DSF, HPLC, UHPLC).
Documents detailed findings in reports and memos suitable to support regulatory document submission and tech transfer to clinical process development teams.
Leads and prioritizes activities within a matrix team.
Communicates experimental findings in written and oral format to project teams.
Contributes toward maintaining team activity management and organizational tools.
Makes detailed observations, interprets data and coordinates results and recommendations into reports and presentations for Sr management.
Maintains complete and accurate laboratory notebooks.
Collaborates with internal teams and external vendors on development projects.
Operates and supervises maintenance of lab instruments.
EDUCATION, EXPERIENCE, KNOWLEDGE AND SKILLS:
PhD in Biochemistry, Bioengineering, Molecular Biology or related scientific field with 3+ years of industry experience, or M.S. with 8+ years of industry experience, or B.S. with 10+ years of industry experience is required.
In-depth knowledge of protein analytical characterization techniques including BLI, SEC, DLS, HPLC, DSF.
Practical knowledge of recombinant protein purification using FPLCs is required.
Strong verbal and written communication and organizational skills.
Demonstrated troubleshooting ability and multi-tasking capabilities.
Experience with vaccine formulation or vaccine adjuvants is a plus.
Practical knowledge of microbial or mammalian protein expression is a plus.
Ability to work independently, with limited direction from project scientists.
Icosavax is a biopharmaceutical company demonstrating its innovative VLP platform technology to develop vaccines against infectious diseases, with an initial focus on life-threatening respiratory diseases. As we are located in Downtown Seattle, parking or reimbursement towards public transportation is offered.
The annual base pay (or hourly rate of compensation) for this position ranges from $108,474 to $162,710. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
At AstraZeneca, we are change makers on the world stage at an exciting frontier of medicine. We are helping to transform healthcare and build pandemic preparedness to protect against future health crises and to bring lasting immunity to people around the globe. We are committed to our central role in addressing pandemic and endemic diseases and ensuring our products continue to reach and benefit millions of people around the world.
Join us and lead the future with an entrepreneurial spirit. With an agile approach and the strength of a global brand, we challenge and change how things are done. Here we combine skills with the power of technology to drive innovation, transform and optimize what we can do. We build on our achievements and think differently about scientific possibilities, developing long-lasting vaccines and highly targeted antibodies. We are always moving forward, challenging the status quo, spotting opportunities, and making thoughtful moves.
Ready to make a difference? Apply now!
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
