Senior Scientist (Translational Sciences, Cell Therapy)
Senior Scientist (Translational Sciences, Cell Therapy)
Introduction to role
Are you prepared to lead the charge in pioneering new frontiers in cell therapy? Join our dynamic team with the ambition to revolutionize treatment options. We are seeking a Senior Scientist to spearhead robust bioanalytical strategies and support our innovative cell therapy pipeline. If you are passionate about cutting-edge science and making a profound impact, this is the role for you!
Accountabilities
Lead design and hands-on execution of robust bioanalytical strategies to support clinical assay endpoints, including but not limited to PK/CK/PD, immunogenicity assays related to cell therapy products to support the AstraZeneca (CAR/TCR) cell therapy pipeline.
Lead and hands-on execution of assay development, qualification/validation of cell-therapy related bioassays and tech transfer (when appropriate) to CROs.
Interpret and integrate complex datasets within programs and across the cell therapy portfolio. Provide written and verbal updates to key stakeholders.
Provide documentation to support regulatory filings, assist in SOP writing and standardization of laboratory methods and procedures.
Essential Skills/Experience
PhD degree in immunology, cellular and/or tumor biology or a related field with 2+ years of relevant industry experience with strong background in cell therapy
Demonstrated experience leading/directing analysis of clinical biospecimens to support clinical trials ideal.
Hands-on experience in T-cell functional characterization assays and multi-parameter flow cytometry.
Experience analyzing clinical biospecimens (including, but not limited to, blood, PBMC, serum and tumor biopsies) to inform clinical trials and/or identification of biomarkers.
Able to evaluate and interpret complex data sets using analysis and visualization software (i.e. Cytobank/OMIQ/FCS Express, Tableau/Spotfire/JMP).
Work cross-functionally and collaboratively with project stakeholders.
Deep understanding of cell therapy biology and up to date with latest analytical methods applicable to characterization of cell therapy products and mechanism of action.
Experience managing assay development teams, overseeing tech transfers, scientific quality and study conduct internally and at CROs.
Ability to interpret complex datasets and exceptional ability to communicate results verbally, in writing and in presentations adapting to different audiences as required.
Ability to prioritize multiple projects and tasks concurrently in a fast-paced environment with minimal direction.
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world.
At AstraZeneca, we follow the science and pioneer new frontiers. Our team is dedicated to Oncology with a vision to eliminate cancer as a cause of death. With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. We fuse cutting-edge science with the latest technology to achieve breakthroughs. Backed by investment, we aim to deliver six new molecular entities by 2025. Our environment is built on courage, curiosity, and collaboration, empowering you to lead at every level and take smart risks that drive patient outcomes.
Ready to make a difference? Apply now and join us on this exciting journey!
The annual base pay (or hourly rate of compensation) for this position ranges from $108,758 to $163,136. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.
