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Assoc. Principal Scientist, Translational Med. Lead, Heme

Местоположение South San Francisco, Калифорния, США Идентификатор вакансии R-105657 Дата публикации 04/16/2021

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.  Join the team dedicated to Hematology/Oncology, with an ambition to eliminate cancer as a cause of death. It’s our big vision that unites and inspires us

We are seeking an Associate Principal Scientist /Translational Medicine Lead in Hematology R&D to join a world class center for discovery and development of innovative cancer medicines.  In this role you will be accountable for delivery of robust, scientifically-driven biomarkers in drug discovery and development programs for hematology programs. You will have the opportunity to impact an industry-leading portfolio of hematology programs from inception through to life cycle management for marketed drugs

Key Responsibilities and Accountabilities:

  • Deriving biomarker strategies based on biology data (internal/external datasets) and implementing within project teams
  • Must be able to lead cross-functional biomarker teams to oversee the delivery of biomarker/diagnostic strategy and interpreting the data related to individual research/clinical development projects
  • Measure pharmacodynamic markers reliably and quantifiably to inform clinical decisions for selecting therapeutically relevant dose/schedules
  • Will be part of cross-functional clinical study management teams (SMT) to lead biomarker/translational strategy and collaborate with clinical operations teams to implement exploratory sample collection and analyses in clinical studies
  • Lead external academic collaborations on novel biomarker/combination focus
  • Should be able to own and contribute to the biomarker/diagnostic related sections in the clinical study protocols, CSRs, and biomarker analysis plans/reports etc.,
  • Collaborate with cross functional teams (global working teams) including biology, translational medicine, and clinical operations etc.,
  • Understanding novel mechanisms of resistance to targeted therapies
  • Work with cross functional leadership to integrate translational support across oncology pipeline
  • Publish work in high quality scientific journals and present at internal/external scientific meetings
  • Supervising/managing lab staff may be required

Education Required:

  • PhD and /or MD with experience in oncology drug development desired
  • Oncology training is required, preferably board certified or board eligible in Oncology and/or Hematology
  • Deep knowledge in disease biology/translational science, with experience in pharmaceutical industry with a focus in Hematology-Oncology

Experience Required:

  • 3+ years’ experience in drug development in pharmaceutical or biotech industries
  • Must have expertise in oncology, cancer cell signaling pathways, biomarker assay development, and translational biology research
  • The ideal candidate should be familiar with several technical methodologies and platforms used for analyzing high-content flow cytometry and genomic data sets (NGS and RNASeq etc.,)
  • Proven experience as an effective scientist and a team player with great motivation,
  • Should be able to fit into a fast-paced work environment with changing project priorities
  • Experience working with primary human clinical trial samples
  • Experience in building partnerships and leveraging relationships with cross functional teams
  • Able to work independently and have excellent oral and written communication skills
  • Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca
  • Proven ability to motivate and develop others


AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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