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Post Doc Fellow - Epigenetic modifier and drug resistance

Местоположение Уолтем, Массачусетс, США Идентификатор вакансии R-066983 Дата публикации 11/28/2019

Postdoctoral Long Title:

Mechanistic and pharmacological study for an epigenetic protein that functions as a resistance mechanism for cancer drug

We’re currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Gatehouse Park, Waltham, MA, USA, you’ll be in a global pharmaceutical environment, contributing to live projects right from the start. You’ll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research in cutting edge laboratories. It’s a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines.

What’s more, you’ll have the support of a leading academic advisor, who’ll provide you with the guidance and knowledge you need to develop your career. This is an exciting area that hasn’t been explored to its full potential, making this an opportunity to make a real difference to the future of medical science.

About AstraZeneca             

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energised and rewarded for their ideas and creativity.

Cancer is one of the greatest challenges facing medical science today. In our Oncology Team, you’ll push the boundaries of science every day to overcome that challenge. We’ve been at the centre of some of the biggest breakthroughs in oncology. In lung cancer, for example, we‘ve brought together complementary expertise to aid discovery and accelerate development in new medicines through a variety of partnerships and initiatives. We’re also early adopters of new technologies to support innovation, including CRISPR, genome editing techniques and a next-generation sequencing platform for companion diagnostics in oncology. But we’re not stopping there. With a world-class pipeline and some of the best experts in the industry, we’re in a great position to develop even more innovative therapeutic approaches.

In this postdoc position, you will be associated with a project aligned with our scientific platform of Tumour Driver and Resistance, aiming to elucidate the molecular mechanism of an epigenetic protein that functions as a resistance mechanism for cancer and define the combination strategy to overcome the drug resistance.

Education and Experience Required:


  • PhD in oncology, cell biology, or related field
  • Strong desire to learn and perform cancer research in an industry setting
  • Expertise in epigenetic oncology and/or DNA damage response
  • Strong scientific background in mechanisms of disease and drug resistance. 
  • Highly motivated, innovative and reliable with the ability to effectively problem solve
  • Flexible, collaborative and team-oriented mind set
  • Strong publication track record


  • Relevant bioinformatic experience

Skills and Capabilities required:

  • Experience with a variety of laboratory, molecular, and cellular biology techniques
  • Experience with key epigenetic techniques including ChIP-seq and/or assays for investigating DNA damage response signalling.

This is a 3 year programme.  2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based.  The role will be based at Waltham, MA with a competitive salary on offer 

To apply for this position, please click the apply link below.

Advert opening date – 8th January 2020

Advert closing date – 7th February 2020

AstraZeneca welcomes applications from all sections of the community.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

If you share our passion for scientific excellence, find out more at; https://careers.astrazeneca.com/students/programmes/post-doctoral-programmes

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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