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In Vivo Senior Scientist, Immuno Oncology Team, Oncology Biosciences

Местоположение Уолтем, Массачусетс, США Идентификатор вакансии R-067483 Дата публикации 12/04/2019

In Vivo Senior Scientist, Immuno Oncology Team, Oncology Biosciences

Waltham, MA

At AstraZeneca Oncology, we are not afraid to do things differently. Our vision is redefining cancer, redefining our solutions to cancer and restoring patients' lives. As a motivated in vivo Senior Scientist, you will join a dynamic and collaborative in vivo biology team in our state of the art Biohub facility in Waltham MA. Your primary responsibility of this position is to build in vivo animal models/assays, conduct PKPD, efficacy, and ex vivo studies to support our oncology R&D portfolio. These efforts will ultimately lead to the identification of drug candidates and the generation of compelling preclinical data packages to progress promising drug discovery projects toward clinical development.

Key Responsibilities:

  • Use expert in vivo technical skills to support our immuno oncology platform by:
    • Developing and working with various in vivo models of cancer ranging from subcutaneous syngeneic tumor models, orthotopic models, PDX models, and humanized models.
    • Conducting in vivo pharmacology studies (tolerability, PK/PD and efficacy) and delivering comprehensive in vivo pharmacology data packages to support both early and late stage drug discovery programs.
    • Conducting flow cytometry analysis of treated tissue samples to explore mechanisms of immune modulation.
  • Demonstrate proficiency and flexibility in working with various programs and databases to capture all study data for broad access by project teams and stakeholders.
  • Work collaboratively across functional disciplines to develop and implement aggressive work plans and timelines.
  • Bring in new technologies and approaches to improve or replace existing disease model platforms that better predict clinical response.

Essential requirements:

  • BS, MS or PhD in pharmacology or related field with a minimum of 2-5 years relevant experience, including experience in Biopharma.
  • Demonstrated expertise in generating and working with various animal models in an industry setting, syngeneic tumor model experience preferred.
  • Experience delivering all aspects of in vivo pharmacology studies in mouse tumor models, including dose-finding tolerability studies, PK/PD studies, and efficacy studies.
  • Demonstrated ability to develop and analyze PD response in various tissues including tumor, draining lymph nodes, and spleen, to evaluate immunological effects of the drug.
  • Ability to work independently, as well as within project teams, and across disciplines.
  • Ability to lead from the bench in problem solving and in the development of innovative solutions.
  • Excellent communication and presentation skills.

Additional experience desired:

  • Experience using humanized mouse model systems.
  • Experience with western blot, ELISA, PCR techniques

AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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Отличная корпоративная культура, отличные рабочие условия, поддерживающий менеджмент. Возможность ротации внутри компании. Они ценят инклюзивность и разнообразие.