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Head of Biomarker Discovery - Respiratory, Inflammation and Autoimmune

Местоположение Гётеборг, Вестра-Гёталанд, Швеция Идентификатор вакансии R-067427 Дата публикации 12/04/2019

Can you envision working in an environment where your scientific excellence within Biomarker Discovery will impact the delivery of life-changing medicine to patients? Are you an experienced leader, ready to use your own and your colleagues’ strengths and differences? Join us today to see where science will take us!

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because an opportunity, no matter how small, can be the start of something big. Within Translational Science and Experimental Medicine (TSEM), we have built an agile environment, with a culture that is science and patient-focused. Our mission is to understand disease mechanisms at the molecular level, identify the most effective target and the right patient population and close the gap between bench science and bedside clinical practice.

A key aspect in translational science is the discovery of biomarkers to drive patient segmentation, demonstrate target engagement, guide dose selection and bridge over to clinical outcome. We are now looking for an excellent scientist to take accountability for discovery of new respiratory precision and target engagement biomarkers and their development and validation. As Head of Biomarker Discovery, you will have a leadership role that requires a strong scientific background as well as excellent people management and interpersonal skills.

You will be located at one of our vibrant R&D sites in Gothenburg, Sweden or Cambridge, UK – depending on your preference.

Main Duties and Responsibilities

As accountable for the delivery of biomarker discovery platforms you will actively be exploiting internally and externally available omics-initiatives to discover and develop novel, innovative biomarker propositions. Agnostic to platform, you will push discovery through established and new technologies, including genomics, transcriptomics, proteomics, metabolomics, epigenomics, lipidomics etc.

Working closely with TSEM colleagues, you will play a pivotal role in:

  • The identification of novel biomarkers for patient segmentation, demonstration of target engagement and the bridge to clinical outcome
  • Extracting knowledge from big omics-datasets
  • Working with the AstraZeneca Centre for Genomics Research to ensure new studies are requested, results are brought into TSEM and that new putative targets are prosecuted
  • The use of experimental medicine studies to identify novel biomarkers and support recall by genotype clinical study design

Your leadership accountabilities will include selection and development of the Biomarker Scientists in your team. Together, you will drive innovation and scientific excellence in Biomarker Discovery through internal scientific development and external collaborations. You will manage resources so that the demand for new biomarkers is met in a flexible, proficient and responsive manner. This includes proposing, establishing and leading external collaborations related to your area of expertise.

You will plan and develop Biomarker Discovery in close collaboration with Department Head and the other leaders in TSEM. Building and maintaining a work environment in which scientific challenge and innovation are maximised, you will work collaboratively with other teams to make AstraZeneca scientifically visible by publishing scientific papers and presenting data at conferences.

Essential Requirements

We believe that you have outstanding interpersonal skills and a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects. You have a solid understanding of the Drug Development Process, from lead identification through clinical development and you are experienced in working efficiently in a matrix team environment.

  • PhD/post-doc in life sciences or other relevant area, alternatively MD with research background
  • Strong leadership skills and ability to be a self-starter complemented by proven leadership and delivery in biomarker discovery, biomarker platforms and application to drug discovery and precision medicine
  • Minimum 10 years of work experience in pharmaceutical R&D, preferably discovery and development
  • Experience and deep understanding of biology, pharmacology, translational medicine and clinical sciences, with pre-eminence in at least one of these areas – respiratory experience desirable

If you are interested, apply now!

Welcome with your application no later than January 31st, 2020.

Additional information

Our Gothenburg site: https://www.astrazeneca.com/our-science/gothenburg.html

Culture and atmosphere of the site: https://www.linkedin.com/feed/update/urn:li:activity:6496327311678410752/

Life in Gothenburg and Sweden: https://www.movetogothenburg.com/

Our Cambridge site: https://www.astrazeneca.com/our-science/cambridge.html

AZRespi #GMD

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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