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Associate Principle Scientist , Immune Engagers group, Oncology

Местоположение Кембридж, Англия, Великобритания Идентификатор вакансии R-138955 Дата публикации 08/01/2022

Do you feel passionate about the possibilities of science to change lives? Do you have a background in T cell immunology? If so, this may be the role for you.

We are seeking a highly motivated Associate Principal Scientist in the T cell immune engagers team with deep scientific and T cell biology and a track record of successful scientific leadership to join our team in Cambridge, UK


At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.

Business Area

AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers.

What you'll do

As an experienced Project Lead within the Immuno-oncology (IO) Bioscience team, you will play a pivotal role in identifying the next generation of innovative IO therapies, and in deepening our understanding of cancer immunology.

Main Duties and Responsibilities

Working in this scientific leadership role you will apply your technical and scientific experience to discover innovative therapeutic approaches. As the bioscience lead on cross-functional project teams you will be responsible for developing and delivering the preclinical strategy to advance immune engager projects through the drug discovery pipeline.

You will stay up to date with the latest discoveries in T cell immunology and tumour immunology, share your expertise both within and beyond the bioscience group, publish peer reviewed articles on your research and develop, and lead, external collaborations. You will matrix manage the project bioscience team, providing expert advice and mentorship, interpreting complex data and making high level recommendations. You will apply your influencing, coaching and mentoring skills to ensure effective cross-functional working within teams. You may also directly line manage bioscience team members, helping to set goals and objectives and coordinating their professional development.

Essential Requirements

  • PhD (or equivalent) in a biological science with 5-10+ years of post-Ph.D research experience in industry. Industry experience is preferred but exceptional candidates with substantial & relevant academic post-doctoral experience will be considered.
  • Deep expertise in immune-oncology particularly around T cell receptor biology, T cell signaling, costimulation and immune synapse, plus broad understanding and enthusiasm for translating basic science into novel cancer therapies
  • General knowledge of biologics drug development
  • Track record of successful scientific leadership (e.g. grants, patents, publications, experience leading projects through milestone transitions in industry/biotec)
  • Technical expertise in preclinical model systems that can be applied to cancer immunology research
  • Excellent scientific communication skills including both written reports (e.g. manuscripts) and oral presentations to broad and diverse audiences

Desirable Requirements

  • Biology / project leadership experience on large-molecule / antibody drug discovery projects either in industry or biotechnology sector.
  • Experience working in the field of IO drug discovery
  • Experience working with successful cross-functional scientific project teams
  • Authorship of patents, grants and/or publications in top-tier scientific journals

Locations: Cambridge UK

Salary: Competitive + Excellent Benefits

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.
  • If you’re curious to know more then please reach out to sophie Halpin.

As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results - pymetrics will not be used solely in our decision-making process but will help us gather additional insight.

Where can I find out more?

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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