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Assoc. Principal Scientist, Hematological Malignancies (Early Onc Discovery)

Местоположение Гейтерсберг, Мэриленд, США Идентификатор вакансии R-105674 Дата публикации 04/18/2021

AZ is seeking a highly motivated and independent Associate Principal Scientist with a proven track record of scientific excellence and project leadership in cancer biology, with an emphasis on hematological malignancies, to join our antibody-drug conjugates (ADCs) portfolio team within the Early Oncology Discovery group in Gaithersburg, MD USA.  As an Associate Principal Scientist, you will be a key member of a team focused on bringing new ADC projects into the portfolio and advancing them through all stages of pre-clinical development. You will have a direct impact on the drug discovery process, both as a project leader and a hands on contributor in the lab. You will bring your theoretical and practical expertise to lead pipeline projects, establishing program priorities and working with a cross-functional team to deliver pre-clinical datasets to support pipeline progression. You will represent the team in front of governance committees and will present program updates at other internal forums. As part of the team, you will also make intellectual contributions to programs across the ADC Portfolio.

Main Responsibilities

  • You will be expected to serve as Oncology biology lead for one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable milestone progression decisions. 
  • Working with the project team, you will help set program strategy, and as biology lead you will be responsible for the delivery of key pre-clinical data that support a strong biological rationale for program progression.
  • Working in the laboratory, you will develop, design, conduct, troubleshoot, and analyze in vitro experiments to assess the function of our ADCs and dissect the mechanism of action of these novel cancer therapeutics. 
  • As a highly organized, self-motivated individual with a strong background in cancer biology, you will stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to antibody drug conjugates, and have a genuine passion for this field of research. 

Essential Requirements

  • PhD Degree with 2+ years of experience, Master's Degree with 5+ years of experience, or a Bachelor’s degree with 10+ years and project leadership experience in a relevant discipline.
  • Demonstrated ability to lead cross functional project teams.
  • Strong knowledge of hematologic cancers, in-vitro and in-vivo pre-clinical models of hematologic cancer, cell biology, molecular biology, and/or biochemistry in the context of cancer biology, with a strong desire for continued learning.
  • Experience with molecular- and cell-based methodologies such as multicolor flow cytometry, fluorescent and live cell microscopy, cytotoxicity assays, ELISA, qPCR, western blotting, and co-immunoprecipitation.
  • Works independently to design and conduct key experiments to support program progression.
  • Excellent verbal and written communication, presentation, and interpersonal skills and evidence of delivery in a team-oriented, collaborative environment.
  • A proven track record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals.
  • Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations.

Desirable Requirements

  • Prior experience in the biopharmaceutical industry preferable but not required.
  • Hands on experience with pre-clinical in vivo models of cancer would be viewed favorably.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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